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ea0073oc12.2 | Oral Communications 12: Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Improved glucose metabolism and decreased weight gain in leptin-resistant, IGFBP2-deficient, db/db mice induced by AZP-3404, a 9-amino acid analog of IGFBP2

Culler Michael D. , Milano Stéphane , Ovize Michel , Delale Thomas , van der Lelij Aart Jan , Clemmons David

Insulin-like growth factor binding protein-2 (IGFBP2) has been demonstrated to be a key mediator of the peripheral actions of leptin, and its deficiency is associated with impaired metabolic function. The metabolic activity of IGFBP2 can be localized to a unique heparin-binding domain (HBD-1) within its structure. AZP-3404 is a 9-amino acid analog of the IGFBP2 HBD-1 that has been demonstrated to increase glucose uptake by differentiated mouse myotubes in vitro, and to increas...

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Endocrine Abstracts

Improved glucose metabolism and decreased weight gain in leptin-resistant, IGFBP2-deficient, db/db mice induced by AZP-3404, a 9-amino acid analog of IGFBP2

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